For applications related to the monitoring and stimulation of the activity of the central and peripheral nervous system
Scaling of a graphene electrode array for brain surgery mapping
The gECoG project is focused on the scaling of a graphene electrode array for use in medical/clinical applications where it is necessary to monitor the brain activity on the surface of the cortex. The device to be scaled is a flexible array of graphene microelectrodes (64 and 128 electrodes) for electrocorticography measurements (ECoG) that are performed during the course of invasive surgeries in the brain, such as those related to the resection of brain tumors or of epileptic focus.
ICN2 and INBRAIN Neuroelectronics (a spin-off participated by ICN2) are working with the objective of increasing the TRL of new invasive implants based on graphene, advancing from the current stage of a preclinical prototype for use in animals towards clinical prototypes of Class III medical devices.
The gECoG project will develop the following activities:
- A.1. Technology scaling. Development of microfabrication processes compatible with the
dimensions and future use of implants in humans. Aspects such as the control of the
mechanical flexibility of the substrate and the homogeneity and performance of the
technology will be developed within the framework of the project.
- A.2. Evaluation of the technology and assembly of the final prototype. The main objectives
are: i) to evaluate the functionality of the new technology in small animal models, ii) to
generate sufficient data on the safety and biocompatibility of the technology, iii) to validate
sterilization procedures, and iv) assembly of the final prototype compatible with existing
medical electronic equipment.
- A.3. Regulatory validation and preparation of clinical trial. This activity includes i) the
preparation of the required documentation to obtain approval from regulatory agencies and
ii) performing functional tests on animal models relevant to the clinical trial.
Prof. Jose A. Garrido is one of the pioneers in the use of graphene for neural interfaces applications. He has more than 141 publications, 78 invited presentations (including keynotes), and has participated in more than 27 projects as Principal investigator.
It is important to highlight the coordination of the BrainCom EU FET proactive project focused on the development of a new generation of neuroprosthetic devices for brain mapping, and his participation from April 2016 to March 2020 as the Deputy of the Work Package 5 related to Biomedical Technologies of the EU Graphene Flagship. Jose is also coordinating the i-VISION project, funded by La Caixa Foundation.
Currently, Jose A Garrido is Chief Scientific Officer of INBRAIN Neuroelectronics, a spin-off of ICN2 which aims at the commercialization of graphene-based neural devices for medical applications.
Contributions from partners
Jose Antonio Garrido
ICN2 is the responsible of the technology scaling by developing the microfabrication processes compatible with the dimensions and future use of implants in humans, and is working on the evaluation of the technology and assembly of the final prototype. ICN2 is also putting efforts on the regulation validation and the preparation of the clinical trial in collaboration with InBrain Neuroelectronics.
INBRAIN Neuroelectronics is working together with the ICN2 with the objective of increasing the TRL of new invasive implants based on graphene, advancing from the current stage of a preclinical prototype for use in animals towards clinical prototypes of Class III medical devices.